These are my thoughts on searching for answers about cholesterol reducing statin drugs and my findings may be disturbing for some people on statin medication. Please be advised.
Please note. I’m not addressing anyone’s personal situation and you should rely on this for informational purposes only. Please consult with your own healthcare provider before acting on any recommendations contained herein.
A new warning from Health Canada about the increased blood sugar levels and the risk of diabetes, including information on how to identify high-risk patients, has been added to the drug labels for the six statins currently marketed in Canada:
Atorvastatin (Lipitor and generics), lovastatin (Mevacor and generics), rosuvastatin (Crestor and generics), simvastatin (Zocor and generics), pravastatin (Pravachol and generics), fluvastatin (Lescol and generics).These are the most popular and available statins medication prescribed today.
Two statin. Cerivastatin and Baycol, were banned because they caused severe muscle breakdown, kidney damage and even death. It’s interesting to note those side effects didn’t show up in drug company pre-launch testing. Also interesting is that in the U.S. This one class of drug creates over 20 billion dollars of revenue for Big-Pharma annually.
This is what the American Food and Drug Administration (FDA) expanded its warning against statin drugs after it was found that statin users have an increased risk of raised blood sugar levels and the development of type 2 diabetes. Cognitive improvement, when in fact, memory loss, forgetfulness and confusion are listed as side effects of cholesterol-lowering statin
Don’t panic or make a mad dash to your Doctor’s office or Healthcare provider or call 911. You can schedule an appointment to see your Doctor and have a serious talk about your concerns with statin medication that is prescribe to lower your risk of a heart attack or stroke by lowering and controlling cholesterol levels.
Report to him that you are experiencing discomfort with the side-effect of the medication and would prefer another approach than pharmaceutical drugs than statin and that you want a safer alternative treatment that is wildly availed in controlling cholesterol and poor circulation in preventing the risk of a possible heart attack or stroke. Because of cholesterol & calcium buildup in your arteries.
Ask your Doctor about Chelation Therapy, that not only helps with cholesterol build-up but it also clears your arteries clean. Another very interesting alternative approach and all natural remedy that I`ve discovered on controlling cholesterol levels and is widely used by thousands of patients the product is called: Choleslo. The heart health product and very affordable compared to the high cost of Chelation Therapy treatments that is available in private clinics in the U.S and Canada.
I`m affiliate member of (HFL solution) program and I do get a small commission for sales made from my blog. I thank you for supporting me to continue blogging and finding other subjects that will inspire you and encourage you to have a better understanding and healthier life.
Formulated by Dr.Sam Robbins a board Certified Endocrinologist and Sports Psychologist and (Co. Founder of HFL solution.) on how to lower and take control of your cholesterol, triglycerides naturally without side-effects and without risking of getting type 2 diabetes like statin medication a known side-effect of the medication. in addition to their previously known side effect of muscle damage and liver disease.
You can get Chelation Therapy treatments by Doctor in their private clinics around the country. Also a very expensive treatment like hundreds of dollars per visit. This alternative treatment has been scientifically studied for over 60 years, around the world by scientists. There are thousands of scientific papers on the subject and books written by Doctors on the benefits of Chelation Therapy without surgery or drugs. ( Not covered by Medicare or insurances Companies) Unfortunately.
(Chelation Therapy was first introduced in the early 40’s for lead poison during the war to remove toxic poisoning in the blood of soldiers exposed to chemical warfare!)
This treatment is only covered (this is my understanding) by (Medicare and Insurance Companies) if you were exposed to lead poisoning like welders expose to toxic fumes while doing their jobs welding copper or lead base materials.
Doctors around the world still prescribe medication like statins for the control and prevention of heart attacks and strokes for the past 20 years and only now are being informed of the truth and realizing that the side-effect are doing more harm than good. Even 10 years ago the medical establishment knew and still prescribe this medication to their patients and, not surprisingly Doctors are still to this date debating the findings.
Here is an interesting research paper on Statin by Martin Hum. PhD. DHD.Nutritionist
Statins’ benefits don’t always outweigh their risks.
Taking these pills you should always reported side effects to taking this medication, including muscle pain, nausea, liver problems and nervous system issues, including peripheral Neuropathie. The list and severity of acknowledged side effects keep growing. Increased risk of diabetes has just been added to stain medication labels be advised that this is a possibility in long turn use.
- Reducing heart attack risk, when in fact there is no direct link between high cholesterol and the increased risk of heart attacks. So, the reduction of cholesterol with statin drugs has no purpose other than to reduce cholesterol. (And our regular readers know that cholesterol is not the villain it is made out to be, so taking statins is pointless.)
- Whatever you do, if you are diabetic and your doctor uses these results (minus the glaring flaws) to persuade you to start taking statins, just say ‘No’.
- Statins: More likely to give you Diabetes than prevent heart attack..
- That statin drugs come with diabetes as a side effect has been known for the last ten years and, in America (but not in the UK), statins have had to carry a warning to this effect since 2012. Now, researchers at McMaster University in Canada have uncovered a novel mechanism in the body by which statins can disrupt your blood sugar control.
- In an article, I described how statin drugs block the production of cholesterol in the liver, but at the same time block the production of a related substance called dolichol, which plays an important role in sugar metabolism and insulin sensitivity. The Canadian study carried out on mice, has found that statins also provoke a very specific immune response that prevents insulin from doing its job properly.
- If the same applies to humans, taking statins is very likely to cause a type of chronic inflammation that leads to insulin resistance and may also damage the cells in the pancreas that produce insulin. Chronic inflammation is a major factor in diabetes and in many other chronic disease conditions.
- This latest research is significant because, although the link between statins and diabetes has been found by many studies, these have only shown that there is an association and have not demonstrated cause and effect. Now there is hard evidence that statins do cause diabetes and that they are likely to do so through at least two different mechanisms in the body.
- Earlier research has linked statins with both increased blood sugar levels and an increased incidence of type 2 diabetes. In one placebo-controlled trial, which was intended to show the cardiovascular benefits of a statin drug, diabetes was diagnosed in 27 percent more patients taking the statin (rosuvastatin) than in those given placebo2. Another study examined the health records of 471,250 patients in Ontario, Canada with no previous history of diabetes, who started taking statins. It compared the diabetes risks of various other kinds of statins against pravastatin, which is considered to have the lowest risk of blood sugar disruption. The results showed that, compared with patients taking pravastatin, the risks of diabetes increased by 22 per cent in those taking atorvastatin, 18 per cent with rosuvastatin and 10 percent with simvastatin.
- When people with diabetes take statins, it is likely that their blood sugar levels will become more elevated and more difficult to control. This will often mean that they will be given higher doses of antidiabetic drugs. And, as I have mentioned several times on The Real Diabetes Truth, the cardiovascular side effects of antidiabetic drugs increase with higher dosages. So, here we have the perfect scenario for maintaining Big Pharma’s profits: two drugs that are prescribed for frequently linked health conditions (people with type 2 diabetes are at higher risk of cardiovascular disease) and which subtly work against each other, so that steadily increasing doses of each are required to keep both conditions ‘stable’.
- Despite the mounting and now incontrovertible evidence that statin drugs increase the risk of people developing type 2 diabetes and make controlling blood sugar more difficult, the medical establishment (for which read the pharmaceutical industry) continues to insist that the benefits of statin drugs outweigh their risks. That stance is looking more and more untenable. Recently, a group of eminent medical specialists, including Sir Richard Thomson, President of the Royal College of Physicians, spoke out against the proposed extension of doctors’ statin prescribing guidelines that would see millions more healthy people being given these dangerous drugs.
- One of the signatories of that letter is Dr David Newman, who is Director of Clinical Research at Mount Sinai School of Medicine in New York. He had this to say about the link between statins and diabetes: ‘The truth is, for most people at low risk of cardiovascular disease, a statin will give them diabetes as often as it will prevent a non-fatal heart attack — and they won’t live any longer by taking the pill.
- Diabetes is just one of the long and ever-growing list of the side effects and dangers of statin drugs. The fact is that the majority of people prescribed statins could do themselves a lot more good by following common sense dietary and lifestyle guidelines. For most people with type 2 diabetes, metformin remains ‘the drug of choice’ in the eyes of many doctors. At the same time, more and more type 2 diabetics are being prescribed insulin. And what happens when these two drugs combine in the body? According to new research, the result could be more heart attacks, strokes and deaths.
- It is well established that heart attacks and strokes are the major cause of death in people with diabetes, so it is not surprising that doctors have tended to prescribe statin drugs to such patients in an attempt to reduce the risk. Statins are a class of drugs that reduce levels of cholesterol, an essential substance in the body that has become the scapegoat for the growing problem of cardiovascular disease. Statins are the world’s best-selling drugs with an estimated 30 million people taking them every day.
- Now, though, the Food and Drug Administration in the United States has issued new labelling guidelines for statin drugs, warning users that taking them can result in elevated blood sugar levels, diabetes and memory loss. This is in addition to their previously known side effects of muscle damage and liver disease.
- The first signs of a link with diabetes were evident as long ago as 2004, with a research report that statin drugs disrupt insulin signalling, the process through which insulin moves glucose from the bloodstream into muscle and fat cells. The implications of this study appear to have been ignored, however, until two recent meta-analyses took a hard look at the link between statins and diabetes.
- The first of these, published in June 2011, involved 33,000 patients enrolled in five major clinical trials using statins. It concluded that, overall, statin use caused around one additional case of diabetes for every 500 patients treated and the higher the dose, the higher the risk. This figure is a bit misleading, though, since it includes earlier trials of the weaker statin drugs. The more potent versions being prescribed today are likely to be linked to a much bigger diabetes problem, especially at higher doses.
- How statins block an essential metabolic pathway
- The second meta-analysis, the results of which were published in January 2012, looked at data from almost 154,000 postmenopausal women. It revealed that women taking statins had a 48 percent greater risk of diabetes, compared with similar women not taking statins. These findings are not just chance occurrences. By blocking the production of cholesterol in the liver, statin drugs also block the production of a related substance called dolichol, which plays an important role in sugar metabolism and insulin sensitivity.
- Incidentally, dolichol levels have been found to be unusually low in people with Alzheimer’s disease, which could go some way towards explaining why statin use has also been linked with memory loss. In his blog he explained the way in which,diabetes and dementia are related and the idea that Alzheimer’s disease may be “insulin resistance in the brain”.
- So, what do you do if you are currently taking statins? Before anything else, talk to your doctor and show him or her these findings. Don’t be fobbed off with assurances that this is a minor side effect that is outweighed by the benefits of taking statins. A 2011Cochrane Review showed, basically, that taking statins does almost nothing to reduce heart attack risk in people who have not previously experienced a heart attack.
- If you already have diabetes, your cholesterol level is not likely to be an additional risk factor. And don’t let your doctor persuade you that statins will reduce your likelihood of peripheral neuropathy (nerve damage) as a complication of diabetes, either. A 2002 population study estimated the risks of neuropathy in statin users and concluded that long term exposure to these drugs significantly increased the risk.
- Eventually, mainstream medicine will accept the simple truth that sugar, not cholesterol, is the real culprit in heart disease. It is a truth that the junk food and soft drinks industry, as well as the pharmaceutical giants making millions from their statin drugs, will go to any lengths to keep from us.
- In the meantime, keep in mind what Hippocrates, the father of medicine, said: “Let food be your medicine and your medicine food”. While drugs may play a useful role in some situations, for the vast majority of us, whether or not we have been diagnosed as having diabetes, eating healthily and getting enough exercise remain our best front line defense against heart disease.
- The health complications that can come with having diabetes, don’t make for cheerful reading. Most people are aware of the increased risks of heart disease and stroke, and of problems with the eyes, kidneys and nervous system. Over the last few years, however, another association has become apparent, with a condition that some people fear more than any other – dementia.
- A link between high blood sugar levels and reduced cognitive performance was suspected as early as 2004, in a study carried out at the University of California, in San Francisco. The link was made when researchers analyzed a mass of data collected over four years on more than 7,000 postmenopausal women, who had taken part in a trial of the drug raloxifene – an anti-oestrogen treatment for women with osteoporosis. They found more than double the incidence of cognitive impairment in women with diabetes or high fasting glucose levels, than in women with normal blood sugar readings.
- The evidence linking type 2 diabetes and Alzheimer’s disease risk is growing rapidly. The results of a 15-year Japanese study, released last September, showed that the incidence of dementia, including Alzheimer’s disease, was around 35 per cent higher in people over 60 with diabetes than in those with normal glucose tolerance. To put that in context, it isn’t a huge increase in risk – from 20 per cent in non-diabetics to 27 percent in diabetics – but it is part of a bigger picture of what happens in the brain when blood sugar and insulin levels are raised.
- Recent research has uncovered the mechanisms involved in the association between diabetes and dementia, although the situation seems far from simple. Magnetic resonance imaging studies have shown diabetic patients to have more constriction in brain blood vessels than control subjects and more atrophied brain tissue (namely a loss of neurons and the connections between them), particularly gray matter. The gray matter includes regions of the brain involved in muscle control, sight, hearing, memory, emotions, and speech. Blood tests also showed high glucose levels to be strongly correlated with higher levels of inflammatory cytokines, which cause chronic inflammation, leading to blood vessel constriction, reduced blood flow and damage to brain tissue.
- Because diabetes damages blood vessels and plays a role in hardening and narrowing the arteries in the brain, it puts sufferers at higher risk of vascular dementia. This is the kind that results from insufficient blood reaching the brain cells, which then become starved of oxygen and glucose, their fuel.
- Your brain can become insulin resistant, too
- As well as too much sugar, too much insulin also damages the brain in ways that can lead to Alzheimer’s disease. Oddly, though, too little insulin also seems to cause problems in the brain and insulin therapy has recently been put forward as a possible treatment for Alzheimer’s disease. It appears that insulin resistance can occur in the brain, as well as in other types of body tissues, and that its effects there could interfere with signalling between brain cells, triggering a cascade of damaging events.
- The good thing to come out of this research is a growing appreciation that keeping both blood sugar and insulin levels stable, which is of course the key to good diabetes control, may also prevent the development of Alzheimer’s disease and other types of dementia. And there is no simpler or more effective means of doing this than through the food you eat.
- In fact, scientists have already begun to investigate the effects of a low glycemic load diet in people with some degree of cognitive impairment. Glycemic load (GL) is a measure of the overall effect that a meal or snack has on blood sugar levels. A study from Seattle, in the US, has found that, after just four weeks on a low GL and low saturated fat diet, visual memory improved, as did the markers for Alzheimer’s disease, including beta-amyloid and tau protein in the cerebro-spinal fluid.
- It is a shame that this study combined low GL and low saturated fat in the same diet, since it is not obvious which of these factors was involved in the improvements seen, or if the combination of both was important. If I were a betting man, though, I’d put my money on the low GL diet causing stabilize blood sugar and insulin levels, in addition to the other beneficial changes seen.
- In my next post, I’ll be showing you how you can start making the change to a low GL diet and reap the benefits of less reliance on medications, less risk of the complications of diabetes, healthier cholesterol and blood pressure readings, weight loss (if you need it) and more energy
- Bear in mind we are not addressing anyone’s personal situation and you should rely on this for informational purposes only. Please consult with your own physician before acting on any recommendations contained herein.
- Siddals KW, Marshman E, Westwood M, Gibson JM. Abrogation of insulin-like growth factor-I (IGF-I) and insulin action by mevalonic acid depletion: synergy between protein prenylation and receptor glycosylation pathways. J Biol Chem. 2004; 279(37):38353-9.
- Preiss D, Seshasai SR, Welsh P, Murphy SA, Ho JE, Waters DD, DeMicco DA, Barter P, Cannon CP, Sabatine MS, Braunwald E, Kastelein JJ, de Lemos JA, Blazing MA, Pedersen TR, Tikkanen MJ, Sattar N, Ray KK. Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis. JAMA. 2011; 305(24):2556-2564.
- Culver AL, Ockene IS, Balasubramanian R, Olendzki BC, Sepavich DM, Wactawski-Wende J, Manson JE, Qiao Y, Liu S, Merriam PA, Rahilly-Tierny C, Thomas F, Berger JS, Ockene JK, Curb JD, Ma Y. Statin use and risk of diabetes mellitus in postmenopausal women in the Women’s Health Initiative. Arch Intern MED. 2012; 172(2):144-152.
- Taylor F, Ward K, Moore TH, Burke M, Davey Smith G, Casas JP, Ebrahim S. Statins for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2011; (1):CD004816.
- Gaist D, Jeppesen U, Andersen M, García Rodríguez LA, Hallas J, Sindrup SH. Statins and risk of polyneuropathy: a case-control study. Neurology. 2002; 58(9):1333-7.